...The Fahlman Lab...

Publications

All Publications in GOOGLE SCHOLAR

* Indicates Fahlman Lab Members.

 

In Press

45. Kramer DA*, Quiroga AD, Lian J, Fahlman RP, Lehner R. Fasting and Refeeding Induces Changes in the Mouse Hepatic Lipid Droplet Proteome Journal of Proteomics. J Proteomics In Press

44. Eldeeb MA*, Leitao LCA*, Fahlman RP. Emerging branches of the N-end rule pathways are revealing the sequence complexities of N-termini dependent protein degradation. Biochem Cell Biol In Press.
Pubmed

2018

44. Maayah ZH, Levasseur J, Siva Piragasam R*, Abdelhamid G, Dyck JRB, Fahlman RP, Siraki AG, El-Kadi AOS. 2-Methoxyestradiol protects against pressure overload-induced left ventricular hypertrophy. Sci Rep. 8(1):2780.
Pubmed

2017

43. Kramer DA*, Eldeeb MA*, Wuest M, Mercer J, Fahlman RP. Proteomic characterization of EL4 lymphoma derived tumors upon chemotherapy treatment reveals potential roles for lysozomes and caspase-6 during tumor cell death in vivo. Proteomics 17(12).
Pubmed

42. Lei L, Hildebrandt MR, Monckton EA, Germain DR, Fahlman RP, Godbout R. Role for Rif1 interacting partner DDX1 in BLM recruitment to DNA double-stranded breaks. DNA Repair. 55: 47-63.
Pubmed

41. Reimer KA, Stark MR, Aguilar LC, Stark SR, Burke RD, Moore J*, Fahlman RP, Yip CK, Kuroiwa H, Oeffinger M, Rader, SD. The sole LSm complex in Cyanidioschyzon merolea associates with pre-mRNA splicing and mRNA degradation factors. RNA. In Press.
Pubmed

2016

40. Eldeeb MA*, Fahlman RP. Phosphorylation impacts N-End Rule degradation of the proteolytically activated for of BMX kinase. J. Biol. Chem. 291: 22757-22768.
Pubmed

39. Rosana ARR, Whitford DS, Fahlman RP, Owttrim GW. Cyanobacterial RNA helicase, CrhR, localizes to the thylakoid membrane region and co-sediments with a degradation-polysome complex in Synechocystis sp. PCC 6803. J. Bact. 198: 2089-2099.
Pubmed

38. Eldeeb M*, Fahlman RP. The N-End Rule: The beginning determines the end. Prot. Pep. Letters. 23: 343-348.
Pubmed

37. Khan SR, Baghdasarian A, Fahlman RP, Siraki AG. SILAC based quantification of global protein expression changes during isoniazid-induced cytoprotection against H2O2 challenge in HL-60 cells. Data in Brief. 29: 823-828
Pubmed

36. Fung AW*, Payoe R*,, Fahlman RP. Perspectives and Insights into the competition for aminoacyl-tRNAs between the translational machinery and for tRNA dependent non-ribosomal peptide bond formation. Life (Basel) 12: 2.
Pubmed

35. Khan SR, Aljuhani N, Morgan AGM, Baghdasarian A, Fahlman RP, Siraki AG. Cytoprotective role of isoniazid against oxidative stress in HL-60 cells.Chem Biol. Interact. 244: 37-48.
Pubmed

34. Chaulk SG*, Ebhardt HA, Fahlman RP. Correlations of MicroRNA;MicroRNA expression patterns reveal insights into microRNA clusters and global microRNA expression patterns. Mol. BioSys. 12: 110-119.
Pubmed

33. Patel A, Vasanthan V, Fu W,  Fahlman RP, MacTavish D, Jhamandas JH. Histamine induces the production of Matrix Metalloproteinase-9 in human astrocytic cultures via H1-receptor subtype Brain Structure and Function. Brain Structure and Function. 221: 1845-1860.
Pubmed

2015

32. Lopez-Orozco J, Para JM, Hole AL, Chaulk SG*, Fahlman RP, Hobman TC. Functional analysis of phosphorylation events in human Argonaute 2. RNA. 12: 2030-2038.
Pubmed

31. Khan SR, Baghdasarian A, Nagar PH*,  Fahlman R, Jurasz P, Michail K, Aijuhani N, Siraki AG. Proteomic profile of aminoglutethimide-induced apoptosis in HL-60 cells: Role of myeloperoxidase and arylamine free radicals. Chem Biol. Interact. 239: 129-138.
Pubmed

30. Alsaikhan, Fahlman R, Ding J, Tredget E, Metcalfe PD. Proteomic profile of an acute partial bladder outlet obstruction. Can Urol Assoc J 9:E114-E121.
Pubmed

29. Fung AWS*, Fahlman RP. The Molecular Basis for the Post-Translational Addition of Amino Acids by L/F transferase in the N-End Rule Pathway. Current Prot. Peptide Science 16:163-180.
Pubmed

28. Marcet-Palacios M, Ewen C, Pittman E, Carmine-Simmen K, Fahlman RP, Bleackley RC. Design and characterization of a novel human Granzyme B inhibitor. Protein Eng Des Sel. 28: 9-17.
Pubmed

2014

27. Ebhardt HA, Nan J, Chaulk SG*, Fahlman RP, Aebersold R. Enzymatic generation of peptides flanked by basic amino acids to obtain MS/MS spectra with 2x sequence coverage. Rapid Comm. Mass Spec. 28: 2735-2743.
Pubmed

26. Glaves JP, Li MX, Mercier P, Fahlman RP, Sykes BD. High-throughput, multi-platform metabolomics on very small volumes: 1H NMR metabolite identification in an unadaltered tube-in-tube system. Metabolomics 6: 1145-1151.

25. Fung AWS*, Leung CCY, Fahlman RP. The Determination of tRNALeu Recognition Nucleotides for Escherichia coli L/F transferase. RNA 20: 1210-1222.
Pubmed

24. Chaulk SG*,  Fahlman RP. Tertiary Structure Mapping of the pri-miRNA miR-17~92. Meth. Mol. Biol. 1182: 43-55.
Pubmed

23. Eldeeb M*, Fahlman RP. The anti-apoptotic form of Tyrosine Kinase Lyn that is Generated by Proteolysis is Degraded by the N-End Rule Pathway. Oncotarget 5: 2714-2735.
Pubmed

22. Khan SR, Baghdasarian A, Fahlman RP, Michail, K and Siraki AG. Current stsus and future prospects of toxicogenomics in drug discovery. Drug Discov. Today 19: 562-578.
Pubmed

21. Fung AWS*, Ebhardt HA*, Krishnakumar KS, Moore J*, Xu Z*, Strazewski P and  Fahlman RP. Probing the Leucyl/Phenylalanyl tRNA Protein Transferase Active Site with tRNA Substrate Analogues. Prot. Pep. Letters 21: 603-614 (2014).
Pubmed

20. Chaulk SG*, Xu Z*, Glover JNM, Fahlman RP. MicroRNA miR-92a-1 Biogenesis and mRNA Targeting is Modulated by a Tertiary Contact within the miR-17~92 microRNA cluster. Nucleic Acids Res. 42: 5234-5244 (2014).
Pubmed

19. Fahlman RP, Chen W, and Overall CM. Absolute Proteomic Quantification of the Activity State of Proteases and Proteolytic Cleavages Using Proteolytic Signature Peptides and Isobaric Tags. J. Proteomics 100: 79-91 (2014).
Pubmed

18. Chaulk SG*, Lattanzi VJ, Hiemer SE, Fahlman RP, Varelas X. The Hippo Pathway Effectors TAZ/YAP Regulate Dicer Expression and miRNA Biogenesis Through Let-7. J. Biol. Chem. 289: 1886-1891 (2014).
Pubmed

2012

17. Xu Z*, Payoe R* and Fahlman RP. The C-terminal proteolytic fragment of the breast cancer susceptibility type I protein (BRCA1) is degraded by the N-end rule pathway. J. Biol. Chem. 287: 7495-7502 (2012).
Pubmed

2011

16. Chaulk SG*, Thede GL, Kent OA, Xu Z*, Gesner EM, Veldhoen RA, Khanna SK, Goping IS, MacMillan AM, Mendell JT, Young HS, Fahlman RP and Glover JNM. Role of pri-miRNA Tertiary Structure in miR-17~92 miRNA Biogenesis. RNA Biology 8(6): 1105 - 1114 (2011).
Pubmed

15. Fung AW*, Ebhardt HA*, Abeysundara H*, Moore J, Xu Z*, Fahlman RP. An alternative mechanism for the catalysis of peptide bond formation by L/F transferase: Substrate binding and orientation. J. Mol. Biol. 409 (4): 617-629. (2011).
Pubmed

14. Payoe R*, Fahlman RP.  Dependence of RelA Mediated (p)ppGpp Formation on tRNA Identity.  Biochemistry 50 (15): 3075-3083. (2011).
Pubmed

2010

13. Ebhardt HA*, Fedynak A, Fahlman RP. Naturally occurring variations in sequence length creates microRNA isoforms that differ in argonaute effector complex specificity. Silence. 1:12 (2010).
Pubmed

2009

12. Ebhardt HA*, Tsang H, Dai D, Liu, Y, Bostan B, Fahlman RP.  Meta-analysis of small RNA sequencing errors reveals ubiquitous post transcriptional RNA modifications.  Nucleic Acids Res. 37 (8): 1202-1210. (2009).
Pubmed

11. Ebhardt HA*, Xu Z*, Fung AW*, and Fahlman RP.  Quantification of the posttranlational addition of amino acids to proteins by MALDI-ToF Mass Spectrometry.  Anal. Chem. 81 (5): 1937-1943 (2009).
Pubmed

10. Dale T, Fahlman RP, Olejniczak M, Uhlenbeck OC. Specificity of the Ribosomal A Site for Aminoacyl-tRNAs. Nucleic Acids Res. 37 (4): 1202-1210. (2009).
Pubmed

2006

9. Fahlman RP, Olejniczak M, Uhlenbeck OC. Quantitative analysis of deoxynucleotide substitutions in the codon-anticodon helix J. Mol. Biol. 355 (5): 887-892. (2006) Pubmed

2005

8. Olejniczak M, Dale T, Fahlman RP, Uhlenbeck OC. Idiosyncratic tuning of tRNAs to achieve uniform ribosome binding. Nat. Str. Mol. Biol. 12 (9): 788-793. (2005) Pubmed

2004

7. Fahlman RP, Dale T, Uhlenbeck OC. Uniform binding of aminoacylated transfer RNAs to the ribosomal A and P sites. Mol. Cell 16 (5): 799-805. (2004) Pubmed

6. Fahlman RP, Uhlenbeck OC. Contribution of the esterified amino acid to the binding of aminoacylated tRNAs to the ribosomal P- and A-sites. Biochemistry 43 (23): 7575-7583. (2004) Pubmed

2003

5. Fahlman RP, Hsing M, Sporer-Tuhten CS, Sen, D. Duplex pinching: A structural switch suitable for contractile DNA nanoconstructions. Nano Let. 3 (8): 1073-1078. (2003)

2002

4. Fahlman RP, Sharma RD, Sen D. The charge conduction properties of DNA holliday junctions depend critically on the identity of the tethered photooxidant. J. Am. Chem. Soc. 124 (42): 12477-12485. (2002) Pubmed

3. Fahlman RP, Sen D. DNA conformational switches as sensitive electronic sensors of analytes. J. Am. Chem. Soc. 124 (17): 4610-4616. (2002) Pubmed

1999

2. Fahlman RP, Sen D. "Synapsable" DNA double helices: Self-select ive modules for assembling DNA superstructures. J. Am. Chem. Soc. 121 (48): 11079-11085. (1999)

1998

1. Fahlman RP, Sen D. Cation-regulated self-association of "synapsable" DNA duplexes J. Mol. Biol. 280 (2): 237-244 (1998) Pubmed